Throughout modern history, treatments for cancer were dominated primarily by very cytotoxic pharmaceuticals and chemotherapy. These traditional means of treating cancer that are successful in killing cancer cells but these toxic medications also destroy many of the bodies healthy cells, causing serious side-effects. The long goal of scientists has always been to target & only kill cancer cells thank to a Functional Medicine Approach to Cancer.
Natural Killer Cells
The human body’s first line of defense against cancer is the natural killer Cells or “NK.” Recent advancements in regenerative medicine and non-toxic radiology have helped us get much further than ever before. Our current therapeutic goals have focused primarily on strengthening your body’s own natural capacity to fight diseases and cancer.(Selathurai et al. 2014)*
The Human immune system is always finding ways to prevent cancer by utilizing NK Cells or Natural Killer cells. Our immune system can and does destroy both precancerous and cancerous cells while recognising and not harming the healthy cells. The Foys Clinic has developed an innovative new Targeted therapies such as Autologous NK cellular immunotherapy using the patient’s own immune system to fight and destroy cancer.
Our unique activated lymphocyte therapy works by infusing harvested autologous Enriched NK cells form the patients immune system’s to directly assault and kill the invading cancer cells. NK Cells or ” T killer cells” are a kind of white blood cell known as a lymphocyte. These lymphocytes are part of congenital immune system in humans.(Knorr et al. 2014)*
These Killer cells play a leading part our bodies ability to reject “foreign mutant cells” such as tumours or virally infected cells. Natural Killer cells are either cytotoxic T cells or natural killer T cells. Tiny granules within its cytoplasm contain very specific proteins (proteases & perforin) that are known as granzymes. A large number of cytokines are produced by Natural T Killer cells including:
- Interleukin (IL-10)
- Tumor necrosis factor α TNFα
NK Cell Therapy in Thailand
Please Note That Not All Patients Qualify for Cancer treatment using Immunotherapy and Enriched NK Cells. Patients with late stage, severe underlying conditions or travel restrictions will not be eligible for the 2-3 week treatment protocol in Bangkok.
Upon expansion of Autologous NK Cells, they are release back into the patient’s blood stream while in close proximity to a targeted cancer cells. The perforin first attaches to the pores of the cancer cell membrane. Then the granzymes molecules can finish the task by entering the cell and causing apoptosis (cell death).
Apoptosis & cell lysis are very different as lysing a virus-infected cell would just discharge virions, whereas apoptosis in cells results in the total destruction of cancer or the virus inside. Depending on the severity and scope of the patients needs each NK Cell dose, may require anywhere from 10 to 25 Billion activated lymphocytes.(Pongpruttipan et al. 2012)*
Natural Killer T cells and nk cell receptors are usually activated naturally in our bodies as a response to interferon signals (bodies distress signal) or macrophage-derived cytokines. The cell antibodies try to “mark” the invading/cancerous cells for destruction. This path is known as ADCC or Antibody Dependent Cellular Cytotoxicity which is basically part of our bodies adaptive immune response system. Naturally circulating cells patrol our bodies looking to destroy any infected or dangerous cells. An ADCC assay is usually required to determine if a person has NK cell deficiency.
Some types of of cells observed in immunotherapy for pancreatic cancers, liver and lung cancers can however evade death by killers cells through tricking the KIR or killer inhibitory receptor of nk cells. Some cancers are able to activate the NK cell “master-off switch,” to evade destruction. For some that means that our natural population of NK cells cannot protect us against the cancerous tumours.(Mimura et al. 2014)* For such cases Allogeneic NK cell therapy is needed.
Other uses of NK Cells with Stem Cells
Besides the treatment for Hepatitis B,C and cancer, (NKT cells) or Therapeutic NK cells are also used in the therapies for arthritis and and gout. NK Cell therapy is also an accepted treatment for use in preventative medicine and several anti-aging protocols.
To learn more about our Alternative Cancer treatments in Thailand using NK Cells please contact us today.
Published Clinical Citations
Knorr, David A, Veronika Bachanova, Michael R Verneris, and Jeffrey S Miller. 2014. Clinical utility of natural killer cells in cancer therapy and transplantation. Seminars in immunology, no. 2 (March 5). doi:10.1016/j.smim.2014.02.002. http://www.ncbi.nlm.nih.gov/pubmed/24618042.
Mimura, Kousaku, Takahiro Kamiya, Kensuke Shiraishi, Ley-Fang Kua, Asim Shabbir, Jimmy So, Wei-Peng Yong, et al. 2014. Therapeutic potential of highly cytotoxic natural killer cells for gastric cancer. International journal of cancer, no. 6 (February 28). doi:10.1002/ijc.28780. http://www.ncbi.nlm.nih.gov/pubmed/24615495.
Pongpruttipan, Tawatchai, Sanya Sukpanichnant, Thamathorn Assanasen, Pongsak Wannakrairot, Paisarn Boonsakan, Wasana Kanoksil, Kanita Kayasut, et al. 2012. Extranodal NK/T-cell lymphoma, nasal type, includes cases of natural killer cell and αβ, γδ, and αβ/γδ T-cell origin: a comprehensive clinicopathologic and phenotypic study. The American journal of surgical pathology, no. 4. doi:10.1097/PAS.0b013e31824433d8. http://www.ncbi.nlm.nih.gov/pubmed/22314189.
Selathurai, Ahrathy, Virginie Deswaerte, Peter Kanellakis, Peter Tipping, Ban-Hock Toh, Alex Bobik, and Tin Kyaw. 2014. Natural killer (NK) cells augment atherosclerosis by cytotoxic-dependent mechanisms. Cardiovascular research, no. 1 (January 26). doi:10.1093/cvr/cvu016. http://www.ncbi.nlm.nih.gov/pubmed/24469537.